Unexpected epileptogenic effect of lethal doses of pentobarbital: a case report

Background: Barbiturate poisoning is rare but potentially fatal. Case Report: We reported a case of barbiturate in 28-year-old woman who recovered from lethal pentobarbital deliberate self-poisoning. The initial blood concentration was 61 mg/L, corresponding to dose. Despite the ingestion high dose pentobarbital, electroencephalogram revealed an unattended pattern compatible with possible nonconvulsive status epilepticus. Following resuscitation maneuvers, appropriate care, and antiseizure medication, patient awakened after 7 days. evolution excellent without neurological deficits at 2 months.Conclusion: expected known effects high-dose reducing suppressing cortical activity brain, present demonstrates that may have epileptogenic effect. Our hypothesis mechanism origin such picture relatively abrupt decrease toxic doses resulting withdrawal phenomenon.